Isocyanates, as a chemical group, are the biggest cause of occupational asthma in the UK. Monitoring of airborne exposures to total isocyanate is costly and cannot assess the effectiveness of protection from exposure. Biological monitoring by analysis of metabolites in urine can be a relatively simple and inexpensive way to assess exposure to isocyanates.
Isocyanates are a family of highly reactive, low molecular weight chemicals. They are widely used in the manufacture of flexible and rigid foams, fibres, coatings such as paints and varnishes and are increasingly used in the automobile industry, auto-body repair, and building insulation materials.
Spray-on polyurethane products containing isocyanates have been developed for a wide range of retail, commercial, and industrial uses to protect cement, wood, fibreglass, steel and aluminium, including protective coatings for truck beds, trailers, boats, foundations and decks.
The most commonly used isocyanates include methylenediphenyl diisocyanate (MDI), toluene diisocyanate (TDI), hexamethylene diisocyanate (HDI) and isophorone diisocyanate (IPDI).
In humans, isocyanates are rapidly metabolised and excreted in the urine as the corresponding diamine. Thus, biological monitoring using pre and post shift urine samples is a useful tool in determining potential exposure.
In the UK the current Biological Monitoring Guidance Value (BMGV) is set at 1μmol isocyanate-derived diamine/mol creatinine.
RPS offer a rapid GC-MS method for the determination of isocyanate metabolites in to meet the BMGV as follows:
For biological monitoring (urine) - Provision of 30ml sample container with stabiliser and prepaid postal return envelope with Category B compliant packaging.
Your contact information:
All fields are mandatory *
Your message has been submitted successfully.
We aim to respond to all enquiries within 48 hours.
If your enquiry is urgent - please contact your local office.
An error occurred. Please refresh the page and try again.